Tig Notaro has a moving two-page spread in the Vanity Fair (January 2013) comedy issue guest-edited by Judd Apatow, in which she discusses how her annus horribilis led to her instantly legendary stand-up routine in which she revealed her cancer diagnosis. Coming off of a life-threatening intestinal illness and her mother's sudden death, Notaro was diagnosed with cancer in both breasts. Deciding to confront it onstage was not an easy decision since she was never known as a personal-issues comic.
"I saw people grabbing their own faces in fear. Other people were knee-slapping. Everyone was processing it in their own time...The big picture of my story is that you never know what's coming around the corner. I need ot sit down, take a deep breath, and connect with where I feel there's humor these days...I could push a stool around Conan's stage for the rest of my life, but some of my other jokes...I just don't think I connect with them anymore."
Be sure to read the whole piece in the magazine or, when it's available, online.