The incident was described as one of the most violent the area has seen.
More after the jump, including a video report ...
Via Crime Watch Daily: Bubbles was known in San Francisco for lively costumes and wigs, having lived in the area for about 20 years.
Police say a tall Asian man left a strip club around 2:50 a.m, fired six shots at Bubbles, then ran away.
No suspects are in custody.